Skip to main content

The Spark of Life – Frances Ashcroft ****

I think most of us are aware that the human body uses both chemical and electrical signalling to control its inner functions, but until I read this book I had certainly never realised that extent to which a rather strange electrical process (strange because it involves the flow not of electrons as in ‘normal’ electricity, but of ions) is handled by ion channels.
After a preface that is a little confusing as she uses terms that aren’t really explained until later, biologist Frances Ashcroft, who spends her days working with ion channels, gives us a brief introduction to electricity. This physics part is by far the weakest bit of the book. For example she doesn’t differentiate between a flow of electrons and the electromagnetic signal in a wire – and some of the history is a little out of date (she says, for instance, that Franklin did the ‘kite in a thunderstorm’ experiment, which is thought unlikely now). But this is only an introductory phase before we get into the meat of the book, which is quite fascinating.
Ashcroft explains how ion channels can open and close to allow a flow of ions through, and how electrical energy is involved in making these essential cell components function. This is absolutely fascinating from the first mention of sodium pumps (I was hoping to come across the medication type proton pump inhibitors, which like many thousands of people I take, but if they were mentioned I missed it). It is remarkable how this essential part of cell function wasn’t properly understood until around 50 years ago.
For the rest of the book we are taken on a tour of the body and the way that ion channels have a powerful influence on everything from poisoning to the functioning of memory. It is quite mind-boggling just how much these tiny channels do for us – always dependent on that electrical motive power.
For me – and it is fair to say that my biology tolerance is pretty low – the book did get a little repetitious in some ways, if only because of the central role of ion channels throughout. I suspect, though, for many, the connection with the functioning of the human body will keep that interest going – and Ashcroft has a light, approachable tone and makes sufficient ventures into the wider picture to keep the reader on-board. Overall a subject that clearly needed writing about, carefully and entertainingly revealed.
Paperback:  
Kindle:  
Review by Brian Clegg

Comments

Popular posts from this blog

Four Way Interview - Tom Cabot

Tom Cabot is a London-based book editor and designer with a background in experimental psychology, natural science and graphic design. He founded the London-based packaging company, Ketchup, and has produced and illustrated many books for the British Film Institute, Penguin and the Royal Institute of British Architects. Tom has held a lifelong passion to explain science graphically and inclusively ... ever since being blown away by Ray and Charles Eames’ Powers of Ten at an early age. His first book is Eureka, an infographic guide to science.

Why infographics?
For me infographics provided a way to present heavy-lifting science in an alluring and playful, but ultimately illuminating, way. And I love visualising data and making it as attractive as the ideas are.  The novelty of the presentation hopefully gets the reader to look afresh. I love the idea of luring in readers who might normally be put off by drier, more monotone science – people who left science behind at 16. I wanted the boo…

A Tale of Seven Scientists - Eric Scerri ***

Scientists sometimes tell us we're in a post-philosophy world. For example, Stephen Hawking and Leonard Mlodinow in The Grand Design bluntly say that that philosophy is 'dead' - no longer required, as science can do its job far better. However, other scientists recognise the benefits of philosophy, particularly when it is applied to their own discipline. One such is Eric Scerri, probably the world's greatest expert on the periodic table, who in this challenging book sets out to modify the philosophical models of scientific progress.

I ought to say straight away that A Tale of Seven Scientists sits somewhere on the cusp between popular science and a heavy duty academic title. For reasons that will become clear, I could only give it three stars if rating it as popular science, but it deserves more if we don't worry too much about it being widely accessible.

One minor problem with accessibility is that I've never read a book that took so long to get started. First t…

Einstein's Greatest Mistake - David Bodanis ****

Books on Einstein and his work are not exactly thin on the ground. There's even been more than one book before with a title centring on Einstein's mistake or mistakes. So to make a new title worthwhile it has do something different - and David Bodanis certainly achieves this with Einstein's Greatest Mistake. If I'm honest, the book isn't the greatest on the science or the history - but what it does superbly is tell a story. The question we have to answer is why that justifies considering this to be a good book.
I would compare Einstein's Greatest Mistake with the movie Lincoln -  it is, in effect, a biopic in book form with all the glory and flaws that can bring. Compared with a good biography, a biopic will distort the truth and emphasise parts of the story that aren't significant because they make for a good screen scene. But I would much rather someone watched the movie than never found out anything about Lincoln - and similarly I'd much rather someon…